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Avenue You Tip: Since artificial nails bond to the top of your natural nails, nail polish remover with acetone works well and keeps the artificial nail bonded. For natural nails, use an acetone-free nail polish remover. Acentone can dry out the natural nail, causing it to become more brittle and fragile. Check the ingredients on your nail polish remover before purchasing to be certain you're buying acetone-free nail polish.